Domain Expert – Pharmacy (UpToDate Lexidrug)

To qualify you must use UpToDate Lexidrug (or Lexicomp) regularly - weekly or more - as a working part of your job, with 2+ years of professional pharmacy experience.

Lexidrug knowledge we require

Core (required of all candidates)

• Knows how to work a full medication-list interaction check to completion — not just confirm a single named pair, but judge severity ratings and mechanism of interaction across the whole list

• Knows how to weigh contraindications, boxed warnings, and warnings/precautions against a specific patient's situation, not just check whether a flag exists

• Knows how to distinguish "not contraindicated" from "appropriate for this patient" — and where in the monograph that second judgment actually gets made

• Knows how to reconcile a Special Alert against monograph content when they conflict — recognizes alerts generally take precedence until reconciled

• Knows how to apply renal/hepatic dose-adjustment logic and calculators correctly given current patient data (labs, weight), not just plug in numbers

Specialized depth (strong working knowledge in at least 2–3 of the following)

• Trissel's IV Compatibility (physical/chemical incompatibility vs. physiological interaction — knows these are distinct problems, not one nested in the other)

• Pediatric/weight-based dosing

• Beers Criteria / geriatric-specific precautions

• Pregnancy and lactation risk categories

• REMS and prescribing/access restrictions (controlled substance scheduling, restricted distribution programs)

• Therapeutic class comparison for alternatives (allergy, shortage, formulary substitution)

• Drug I.D. and patient education / multi-language handouts

What you'll do

• Confirm an interaction, dosing, or contraindication finding holds up against the patient's full medication list and chart — not just the two drugs named in the question

• Catch missed interactions, stale patient data (outdated labs/weight) driving a wrong dose, and monograph guidance superseded by a newer Special Alert

• Judge completeness: is the full clinical picture (all active meds, current labs, comorbidities) accounted for, or was the question scoped too narrowly

• Distinguish "permitted" from "appropriate" — flag when a drug clears interaction/contraindication checks but is still a poor choice for this specific patient

• Verify that a correct clinical conclusion is actually carried through — order updated, prescriber notified, chart/note documented — not just identified and left there

Requirements

• Frequent Lexidrug (or Lexicomp) use - weekly or more - in your current or recent role

• 2+ years of professional pharmacy experience, inpatient/hospital setting strongly preferred

• Reflexive use of Interactions, Trissel's, and monograph sections; can spot a missed interaction, a stale dose calculation, or superseded guidance on sight

• PharmD and active pharmacy license, or equivalent verification-heavy clinical experience

• Strong working knowledge in at least 2–3 specialized areas above, tied to your practice setting (e.g., ICU, oncology, pediatrics, geriatrics)

• Comfort judging whether a correct clinical finding was properly followed through into the chart, order, and care-team communication

• Prior data annotation, labeling, or AI evaluation experience is a plus